Benefits of Rapamycin
- Promotes Autophagy: Directly stimulates the cellular cleaning process, clearing toxic debris and promoting cellular rejuvenation.
- Targets Senescence: Inhibits mTOR, combating cell senescence and leading to increased longevity and healthier cellular function.
- Reduces Systemic Inflammaging: Reduces senescent-associated inflammation, promoting overall well-being and vitality.
- Strengthens Immune Function: Decreases inflammation, enabling immune stem cells to operate more efficiently.
- Enhanced Vitality: Improves overall energy levels, giving a greater sense of vitality and vigor.
- Improved Cognitive Function: Supports brain health and potentially enhances cognitive function, including memory and mental clarity.
- Increased Physical Performance: Reduces cellular senescence and enhances cellular regeneration, improving endurance and strength.
- Reduced Inflammation and Joint Discomfort: Reduces systemic inflammation, alleviating joint discomfort and promoting mobility.
- Better Skin Health: Targets senescent cells to combat skin aging, improving collagen production, and skin elasticity.
What Can I Expect?
Some common positive effects that patients see after starting oral rapamycin is a reduction in inflammation, such as decreased joint pain. These results can be seen pretty quickly in some patients and for others it can take longer. Other positive benefits that patients may see include enhanced vitality, physical performance, and skin health. These benefits can vary from person to person as each person responds to the medication differently. Oral Rapamycin is more of a long game along with dietary and lifestyle practices for longevity.
Molecular Pathways of Rapamycin
Rapamycin impacts several aging pathways within the body:
- mTOR Pathway: Inhibits mTOR, reducing protein synthesis, promoting autophagy, and affecting lipid and glucose metabolism.
- Autophagy: Promotes autophagy, reducing cellular damage and slowing the aging process by clearing damaged proteins and organelles.
- Insulin/IGF-1 Signaling: Impacts insulin and IGF-1 signaling, with reduced IGF-1 shown to increase lifespan.
- Senescence and Inflammation: Reduces cellular senescence and inflammation, factors contributing to aging.
- Sirtuins: Potential interaction with sirtuin pathways, proteins that play roles in aging.
- AMPK Pathway: May indirectly influence AMPK activity, a metabolic master switch linked to lifespan extension.
- Mitochondrial Function: Promotes mitochondrial health and biogenesis, supporting cellular health and longevity.