Contraindications of LDN
- Use of Opioid Medications: Patients taking opioid pain medications should not use LDN, as it blocks opioid receptors and can precipitate withdrawal symptoms
- Liver Disease: While full-dose naltrexone (50mg) carries warnings against use in patients with liver disease, this caution extends to LDN for patients with acute hepatitis or liver failure
- Organ Transplants: Patients who have received organ transplants or are on immunosuppressive medications should avoid LDN, as it may counteract the effects of these medications
- Chemotherapy: Consult with a healthcare provider if undergoing chemotherapy, as it is unclear whether LDN may affect the efficacy of chemotherapy drugs
- Tamoxifen: Patients taking tamoxifen should consult their healthcare provider before using LDN due to potential interactions
Patients should be warned that using LDN in conjunction with nicotine and alcohol may interact by reducing cravings and addictive behaviors, but it is essential to avoid excessive use of these substances as they can interfere with LDN’s effectiveness and potentially exacerbate side effects.
Side Effects of LDN
- Like all medications, LDN can have side effects, though they are generally considered rare and mild. They can include insomnia, vivid dreams, headache, anxiety, and potential gastrointestinal upset.