Longevity Standard Lab – Healthspan

The Longevity Starter Panel synthesizes crucial health indicators — a CMP, CBC, lipid profile, HbA1C, Hs-CRP, and ApoB. By interpreting these core biomarkers, our algorithms provide a detailed biological age assessment, empowering you with targeted insights to enhance your metabolic efficiency, cardiovascular health, and systemic resilience for a proactive approach to longevity.

This panel is designed to deliver a holistic view of your health, focusing on key aspects such as metabolic efficiency, blood health, cardiovascular risk, and systemic inflammation. By utilizing advanced algorithms, the panel goes beyond traditional assessments to calculate your biological age, providing a deeper insight into your body's aging process compared to your chronological age. This analysis is crucial in identifying potential health risks and areas for improvement, guiding you toward a personalized pathway for optimizing your longevity and maintaining a robust metabolic engine.

Rapamycin Subscription:

With an active Rapamycin membership, patients automatically receive a LabCorp requisition every 6 weeks within their portal and via email that can be downloaded and schedule a time to complete the lab work.

Getting lab work completed 6 weeks after starting the protocol is recommended to monitor progress. Following that, patients may continue to receive lab tests every 6 weeks. If you are doing well, the interval can be extended to every 3 months.

Cost without a Rapamycin Subscription:
$40

Markers Included:

1. Biological Age

2. Metabolic Markers

Glucose: Glucose is considered an important biomarker because it is the primary source of energy for the body's cells. Glucose levels can indicate how well the body is able to manage blood sugar and can also be an important marker of metabolic health and the overall function of the endocrine system.
Hemoglobin A1C: Hemoglobin A1c (often simply referred to as A1c) measures the average blood sugar (glucose) levels over the past 2-3 months. It does so by gauging the percentage of hemoglobin — a protein in red blood cells that carries oxygen — that's coated with sugar. The A1c test provides insight into long-term glucose control and metabolic health.
Total Cholesterol: Total cholesterol is a measure of the total amount of cholesterol in your blood, which includes LDL (low-density lipoprotein) cholesterol, HDL (high-density lipoprotein) cholesterol, and triglycerides. In functional medicine, cholesterol is not just viewed in isolation but in context with other markers and the patient's overall health. Cholesterol is essential for building cell membranes, producing hormones, and other functions.
LDL Cholesterol: LDL (low-density lipoprotein) cholesterol, often referred to as “bad cholesterol”, is considered a biomarker for cardiovascular disease risk. Elevated levels of LDL are associated with a higher risk of developing heart disease and stroke.
VLDL Cholesterol: VLDL stands for Very Low-Density Lipoprotein. It is one of the types of lipoproteins found in your blood and is responsible for transporting triglycerides, a type of fat, from the liver to various tissues in your body. VLDL is often mentioned in the context of cholesterol testing and heart health.
HDL Cholesterol: HDL (High-Density Lipoprotein) cholesterol, often referred to as "good cholesterol," plays a vital role in cholesterol metabolism. HDL helps transport cholesterol from the arteries and other parts of the body back to the liver, where it's processed and removed from the body. Higher levels of HDL are associated with a reduced risk of cardiovascular diseases.
Triglycerides: Triglycerides are a type of fat (lipid) found in the blood. The food you eat gets converted into glucose for immediate energy use or stored as triglycerides in fat cells. Hormones regulate the release of triglycerides from fat tissue to meet energy needs in between meals. Elevated triglyceride levels is a strong indicator of poor metabolic health.
Triglyceride:HDL C Ratio: The Triglyceride:HDLC Ratio predicts the risk of insulin resistance and LDL particle size. Insulin resistance is a condition in which the body's cells have a reduced response to the hormone insulin, leading to elevated blood sugar levels and an increased risk of type 2 diabetes. LDL particle size refers to the size of the low-density lipoprotein cholesterol particles in the blood, with smaller particles being associated with a higher risk of cardiovascular disease. A higher Triglyceride to HDL Cholesterol Ratio is a sign that an individual may be at greater risk of both insulin resistance and having smaller, potentially more harmful LDL cholesterol particles.
Apolipoprotein B (Apo B): Apolipoprotein B (Apo B) is a protein found in certain types of cholesterol carriers in your blood, specifically LDL (low-density lipoprotein) and VLDL (very low-density lipoprotein). Apo B plays a key role in the development of atherosclerosis, which is the buildup of fats and cholesterol in and on your artery walls (plaque), making arteries narrower and less flexible. High levels of Apo B are linked to various health issues like genetic disorders affecting lipid levels, hypothyroidism, obesity, and complications from diabetes. Conversely, lower levels of Apo B might be seen in overactive thyroid (hyperthyroidism), long-term anemia, or poor nutrition. Apo B is a crucial indicator for evaluating the severity of coronary artery disease and the risk of diabetic retinopathy. It's also closely related to complications from obesity.

3. Immune Markers

C-Reactive Protein: C-Reactive Protein (CRP) is a protein produced by the liver in response to inflammation. High levels of CRP can indicate inflammation in the body, which can be due to a variety of conditions, including infections, chronic diseases, and other inflammatory conditions. CRP is a valuable marker to assess the body's inflammatory status, which can be a root cause or contributing factor to numerous health conditions.
WBC: White blood cells (WBCs) are an important biomarker as they are key indicators of the body's immune system function. Elevated WBC count may indicate an infection or inflammation, while a decreased count can indicate a compromised immune system. WBC counts along with other biomarkers such as C-reactive protein (CRP) can provide a holistic view of a patient's overall health and help identify the root cause of any health issues.
Neutrophil-Lymphocyte Ratio: When the body is under stress, such as during a physical or physiological challenge, there are changes in the types of white blood cells in the bloodstream. One notable change is an increase in the number of neutrophils and a decrease in the number of lymphocytes. The Neutrophil:Lymphocyte Ratio (NLR) is a measure that takes both of these changes into account, and it is more sensitive in detecting stress than looking at these changes individually. Two important factors influencing NLR are cortisol (a hormone produced in the body) and catecholamines like adrenaline. Elevated levels of cortisol tend to increase the number of neutrophils while simultaneously reducing the number of lymphocytes, contributing to an elevated NLR. It's important to note that NLR doesn't solely indicate infection or inflammation; it can also increase due to various forms of stress, like severe dehydration.
Lymphs (Absolute): Lymphocytes are a type of white blood cell that plays a vital role in the immune system. They are involved in producing antibodies and killing foreign pathogens, including viruses and cancer cells. The absolute lymphocyte count (ALC) measures the number of lymphocytes in a given volume of blood.
Lymphs: Lymphocytes are a type of white blood cell that play a central role in the immune system. They help fight infections and are crucial in the body's defense against diseases. Lymphocytes consist of three main types: B cells, T cells, and natural killer (NK) cells. Each type has a unique function in defending the body against pathogens. When your lymphs are in optimal levels it suggests that your immune system is functioning well and is prepared to respond to potential threats, such as infections or foreign substances.
Monocytes (Absolute): Monocytes, a vital type of white blood cell, are key players in infection defense, debris clearance (including dead cells), and immune system support. The absolute monocyte count indicates the exact quantity of monocytes in a blood sample. An optimal range of this count signifies that your body has a balanced number of monocytes, essential for combating infections and managing cellular waste.
Monocytes: Monocytes are a type of white blood cell that plays a vital role in the immune system, particularly in responding to chronic inflammation and fighting certain kinds of infections. They circulate in the bloodstream and, when needed, migrate to tissues, where they transform into macrophages and dendritic cells to combat pathogens and clear away dead cells.
Neutrophils (Absolute): Neutrophils, a crucial type of white blood cell, are fundamental in defending the body against bacterial infections. The absolute neutrophil count (ANC) quantifies the exact number of neutrophils present, providing a vital indicator of immune status and susceptibility to infections. Monitoring ANC is essential for assessing one's ability to combat bacterial threats effectively.
Neutrophils: Neutrophils are the most abundant type of white blood cell and are a crucial part of the innate immune system. They are the body's first line of defense against bacterial and fungal infections and respond quickly to inflammatory signals in the body.
Eosinophils: Eosinophils, a specialized type of white blood cell, are paramount in fighting parasitic infections and are actively involved in allergic responses. An optimal range in your absolute eosinophil count indicates that your body is not currently exhibiting signs of allergic reactions or parasitic infections, suggesting a well-regulated immune response in these contexts.
Basophils: Basophils are a type of white blood cell, part of the immune system, that plays a role in the body's response to certain allergies and other conditions. They are responsible for releasing histamine during allergic reactions and are involved in inflammatory reactions. They make up the smallest proportion of circulating white blood cells.
Immature Granulocytes: Immature granulocytes are a type of white blood cell that is not fully developed. The percentage of these cells in the blood can be an important indicator of immune system activity. Elevated levels may suggest an ongoing infection, inflammation, or other conditions stimulating the bone marrow to produce more white blood cells.

4. Organ Markers

RBC (Red Blood Cell Count): Measures the number of red blood cells in a volume of blood. Red blood cells are responsible for carrying oxygen from the lungs to the rest of the body. Abnormal RBC levels can indicate conditions like anemia (low RBC) or polycythemia (high RBC), affecting the body's ability to transport oxygen effectively.
Hemoglobin: The protein in red blood cells that carries oxygen throughout the body; low levels can indicate anemia, while high levels might suggest dehydration or other conditions.
Hematocrit: The proportion of red blood cells in the blood, used to assess anemia, hydration status, and overall blood volume.
MCV (Mean Corpuscular Volume): Measures the average size of red blood cells, helping to classify types of anemia (microcytic, normocytic, macrocytic).
MCH (Mean Corpuscular Hemoglobin): Indicates the average amount of hemoglobin inside a single red blood cell, helping to diagnose and classify anemia.
MCHC (Mean Corpuscular Hemoglobin Concentration): Measures the average concentration of hemoglobin in a given volume of red blood cells, useful in diagnosing the type of anemia.
RDW (Red Cell Distribution Width): Indicates the variation in the size of red blood cells; higher RDW can indicate a mix of cell sizes, often seen in certain types of anemia.
Platelets: Small blood cells involved in clotting; low levels can increase bleeding risk, while high levels might indicate a risk of clotting or other conditions.
Protein: The total protein in your blood refers to the combined amount of different proteins found in your bloodstream. Among these proteins, albumin and globulin are the most common. These proteins have important roles in your body, such as transporting various substances, helping enzymes work properly, producing antibodies to fight off infections, aiding in blood clotting, and regulating the balance of fluids in your body.
Albumin: Albumin is the most abundant protein in blood plasma, making up about 50% of total serum proteins. It plays several crucial roles, including maintaining osmotic pressure (helping to keep fluid within the bloodstream rather than leaking into tissues), transporting hormones, vitamins, and drugs, and serving as a buffer to maintain pH levels. Abnormal albumin can indicate malnutrition, liver or kidney disease, or a digestive inflammatory condition (Crohn’s or Celiac) resulting in malabsorption.
BUN (Blood Urea Nitrogen): BUN, or blood urea nitrogen, is a biomarker that is used to evaluate kidney function. The kidneys filter waste products from the blood, including urea, which is a byproduct of protein metabolism. When the kidneys are functioning properly, they remove urea from the blood and excrete it in the urine. Elevated levels of BUN in the blood, therefore, can be an indication that the kidneys are not working properly.
Creatinine: Creatinine is a waste product that is produced by muscle metabolism and excreted by the kidneys. It is commonly used as a biomarker to assess kidney function. Elevated levels of creatinine can indicate that the kidneys are not functioning properly, which can be caused by a variety of conditions such as chronic kidney disease, dehydration, or medication-induced kidney toxicity.
BUN/Creatinine Ratio: The Blood Urea Nitrogen to Creatinine Ratio (BUN/Creatinine Ratio) is a calculated value that compares the levels of blood urea nitrogen (BUN) and creatinine in the blood. BUN and creatinine are both waste products produced by the body as a result of normal metabolism, particularly in the breakdown of proteins. The BUN/Creatinine Ratio can provide insights into kidney function and hydration status. An optimal BUN-to-creatinine ratio suggests that your kidneys are working well and effectively removing waste products from your body. This is a positive sign for your kidney health.
eGFR (Estimated Glomerular Filtration Rate): eGFR, or estimated glomerular filtration rate, is a measure of how well the kidneys are functioning. It is calculated based on a blood test for creatinine, a waste product produced by muscle metabolism.
Sodium: Sodium is an essential electrolyte that plays a vital role in maintaining proper fluid balance and nerve and muscle function in the body. Sodium levels are measured by a test called a serum sodium test.
Potassium: Potassium is an essential mineral that plays a critical role in many physiological processes, including muscle and nerve function, heart rhythm, and fluid balance. In functional medicine, potassium levels are considered a biomarker for overall health, and imbalances in potassium can indicate underlying conditions or deficiencies.
A/G Ratio (Albumin/Globulin Ratio): The A/G ratio represents the relationship between albumin and globulin, two primary protein groups found in the blood. Albumin is responsible for maintaining the osmotic pressure of blood, aiding in the transport of small molecules, and providing a reservoir of essential amino acids. Globulins are a mixed group of proteins that include enzymes, antibodies, and carrier proteins. The A/G ratio can provide insights into liver function, nutritional status, and chronic inflammatory or immune processes. Optimal A/G ratio levels suggest that your liver function and protein synthesis are balanced, and there aren't signs of chronic inflammation or immune-related abnormalities reflected in this specific ratio.
AST (SGOT): AST (Aspartate Aminotransferase), formerly known as SGOT (Serum Glutamic-Oxaloacetic Transaminase), is an enzyme that is found in various tissues of the body, including the liver, heart, muscles, and kidneys. It is most commonly used as a marker of liver health, as elevated levels can indicate liver damage or inflammation.
ALT: Alanine aminotransferase (ALT), formerly called serum glutamic-pyruvic transaminase (SGPT), is an enzyme primarily found in the liver. It plays a role in converting alanine, an amino acid, into glucose that can be used for energy. ALT levels are often measured to evaluate liver health; elevated levels can indicate liver damage or inflammation.
Alkaline Phosphatase: Alkaline Phosphatase (ALP) is an enzyme found throughout the body, but it is primarily associated with the liver, bones, kidneys, small intestine, and placenta. Elevated levels of ALP can indicate liver obstruction, liver disease (such as cirrhosis), gastrointestinal issues, bone disorders, hyperphosphatemia, or hyperparathyroidism. ALP levels may be decreased due to nutrient deficiencies, specifically zinc, magnesium, and/or Vitamin C.
Globulin: Globulins are a group of proteins in the blood, made in the liver and the immune system. They play various roles, including in the immune response, binding and transporting other molecules in the blood, and clotting.
Bilirubin: Bilirubin is a yellow compound that's produced when red blood cells break down. It's processed by the liver, excreted into the bile, and eventually eliminated from the body through feces. Total bilirubin measures both direct (conjugated) and indirect (unconjugated) bilirubin. Bilirubin, a byproduct of red blood cell breakdown, is derived from the heme in hemoglobin and excreted in the bile. Elevated levels in the blood are associated with liver or gallbladder disorders, inflammation, increased RBC breakdown, and certain medications. Determining whether the increase in bilirubin is due to the conjugated or unconjugated form will help identify the cause of the increase. Low total bilirubin has been closely associated with cardiovascular disease, stroke, metabolic syndrome, and diabetic peripheral neuropathy. Elevated total bilirubin can be seen with liver and gallbladder disorders, inflammation, and certain medications.
Carbon Dioxide (CO2): Carbon dioxide (CO2) is a measure of bicarbonate in the blood, which helps to maintain the body's pH balance. CO2 (in the form of bicarbonate) is essential in the buffering system to maintain proper acid-base balance in the body. When your CO2 levels are within the optimal range, your body is maintaining a proper acid-base balance. This balance is crucial for all the metabolic processes and the functioning of enzymes in your system. From a longevity medicine perspective, it indicates good metabolic health.
Anion Gap: The anion gap blood test shows whether your electrolytes are out of balance or if your blood is too acidic or not acidic enough. Too much acid in the blood is called acidosis. Too little acid in your blood is called alkalosis. Maintaining an optimal Anion Gap is essential for overall well-being. It plays a role in assessing the acid-base balance in your body and can be used to help diagnose certain medical conditions. Mildly lower Anion Gap levels can sometimes be associated with factors like mild metabolic conditions or dietary choices.
Calcium: Calcium is a vital mineral found primarily in the bones and teeth, but it's also essential for various physiological functions, such as muscle contraction, nerve function, blood clotting, and intracellular signaling. A small percentage of calcium is found in the blood, and its levels are regulated by various hormones, including parathyroid hormone and vitamin D.

Commonly Asked Questions

What can I expect from the booking process?

Booking a Longevity Starter test is quick and convenient, with access to over 2000 partner labs nationwide. Simply schedule your appointment online, and choose a lab location that suits your schedule for a hassle-free blood draw.

How are the results presented, and how can I interpret them?

Longevity Started transforms complex biomarker data into easy-to-understand visuals and tailored reports, providing clarity and actionable insights. The results will empower you to make informed decisions about your health and longevity.

How long will it take to receive my lab results?

Lab results are typically available within 2-3 weeks.

How do I prepare for the test?

To ensure accurate results, please follow these preparation guidelines:

Fasting: Do not eat or drink anything except water for 12 hours before your test.
Exercise: Avoid strenuous physical activities for 12 hours prior to the test.
Hydration: Stay hydrated by drinking plenty of water, but avoid other beverages.
Lab Order Form: An electronic copy will be attached to your confirmation email. There is no need to print it; simply bring it on your mobile device.
Identification: Please bring a valid photo ID.

What should I do after the test?

Some individuals may feel light-headed or dizzy after a blood draw. It's advisable to bring a small snack or drink to consume afterward to help you stabilize and feel more comfortable.