Frequency:
- Compounded rapamycin is generally administered once per week.
- Age Considerations: For individuals under 30, compounded rapamycin is typically not recommended unless for specific therapeutic reasons. If younger patients proceed, we suggest bi-weekly dosing with scheduled breaks throughout the year due to bioavailability concerns.
Dosage:
- Starter Dose: Begin with 3 mg per week, understanding that compounded rapamycin’s lower bioavailability often necessitates higher dosing compared to generic formulations.
- 3 mg Incremental Increases: Each compounded pill is 3 mg, so any dosage increase will occur in 3 mg increments (e.g., 6 mg, 9 mg). This step-wise increase aligns with the need to account for potential absorption inconsistencies, allowing for gradual adjustment to achieve therapeutic levels.
- Weight-Based Dosing Formula:
- Weight in Kg * 0.075 = Dose in mg
- Given bioavailability issues, this may yield in too low of a dose.
- Weight in Kg * 0.075 = Dose in mg
- Maximum Dose Recommendation: Avoid exceeding 15 mg per week with compounded rapamycin.
Dosing Nuances Due to Bioavailability Variability:
- Higher Doses Often Required: To counteract lower bioavailability, patients typically require higher doses of compounded rapamycin to reach comparable blood levels achieved by generic versions.
- Absorption Factors: Taking compounded rapamycin with a high-fat meal may help with absorption, though the effect remains inconsistent. We also advise against grapefruit and grapefruit juice, which can interfere with metabolism, adding further variability to blood levels.