Empirical Studies
Anti-Aging Potentials of Methylene Blue for Human Skin Longevity: This study demonstrated that methylene blue improved skin viability, promoted wound healing, increased skin hydration, and enhanced dermal thickness in a 3D human skin model. It also upregulated essential components for healthy skin, such as elastin and collagen.
Common Antioxidant Could Slow Symptoms of Aging in Human Skin: Researchers found that methylene blue could slow or reverse signs of aging in cultured human skin cells and simulated skin tissues by decreasing reactive oxygen species and reducing cell death.
The Potentials of Methylene Blue as an Anti-Aging Drug: This review discusses methylene blue's antioxidative properties and its role in improving mitochondrial function, which may contribute to its potential as an anti-aging therapeutic.
An Updated Prioritization of Geroscience-Guided FDA-Approved Drugs Repurposed to Target Aging: Methylene blue (MB) is highlighted as a promising geroprotective molecule in the referenced article due to its ability to mitigate mitochondrial dysfunction, a key driver of aging. By acting as an electron donor and acceptor in the electron transport chain, MB enhances mitochondrial respiration and reduces oxidative stress. The article also underscores MB's role in maintaining cellular homeostasis and delaying senescence, further supporting its potential in addressing age-related diseases and promoting longevity. Its multifaceted mechanisms position MB as a valuable candidate in the field of geroprotection.
https://esmed.org/MRA/mra/article/view/5138/99193547794
From Mitochondrial Function to Neuroprotection-an Emerging Role for Methylene Blue
MB can act as an alternative electron carrier within the mitochondrial electron transport chain, effectively enhancing cellular respiration and reducing oxidative stress. This dual action positions MB as a promising therapeutic agent for neurodegenerative disorders characterized by mitochondrial dysfunction, such as Alzheimer's disease, Parkinson's disease, and stroke.